Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status
Identifieur interne : 001950 ( Main/Exploration ); précédent : 001949; suivant : 001951Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status
Auteurs : Matthias Dürst [Allemagne] ; Heike Hoyer [Allemagne] ; Christoph Altgassen [Allemagne] ; Christiane Greinke [Allemagne] ; Norman H Fner [Allemagne] ; Alba Fishta [Allemagne] ; Mieczyslaw Gajda [Allemagne] ; Ute Mahnert [Allemagne] ; Peter Hillemanns [Allemagne] ; Thomas Dimpfl [Allemagne] ; Miriam Lenhard [Allemagne] ; K. Ulrich Petry [Allemagne] ; Ingo B. Runnebaum [Allemagne] ; Achim Schneider [Allemagne]Source :
- Oncotarget [ 1949-2553 ] ; 2015.
Abstract
Up to 15% of patients with cervical cancer and pN0-status develop recurrent-disease. This may be due to occult metastatic spread of tumor cells. We evaluated the use of human-papillomavirus-(HPV)-mRNA as a molecular marker for disseminated tumor cells to predict the risk of recurrence. For this prospective, multi-center prognostic study, 189 patients free of lymphnode metastases by conventional histopathology could be analyzed. All patients underwent complete lymphadenectomy. Of each sentinel node (SLN) a biopsy was taken for the detection of HPV-E6-E7-mRNA. Median follow-up time after surgery was 8.1 years. HPV-mRNA could be detected in SLN of 52 patients (27.5%). Recurrence was observed in 22 patients. Recurrence-free-survival was significantly longer for patients with HPV-negative SLN (log rank
Url:
PubMed: 26008982
PubMed Central: 4673218
Affiliations:
- Allemagne
- Basse-Saxe, Bavière, Berlin, District de Haute-Bavière, District de Kassel, Hesse (Land)
- Berlin, Cassel (Hesse), Hanovre, Munich
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000386
- to stream Pmc, to step Curation: 000386
- to stream Pmc, to step Checkpoint: 000F48
- to stream Ncbi, to step Merge: 007414
- to stream Ncbi, to step Curation: 007414
- to stream Ncbi, to step Checkpoint: 007414
- to stream Main, to step Merge: 001952
- to stream Main, to step Curation: 001950
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status</title><author><name sortKey="Durst, Matthias" sort="Durst, Matthias" uniqKey="Durst M" first="Matthias" last="Dürst">Matthias Dürst</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Hoyer, Heike" sort="Hoyer, Heike" uniqKey="Hoyer H" first="Heike" last="Hoyer">Heike Hoyer</name><affiliation wicri:level="1"><nlm:aff id="A2"> Institute of Medical Statistics, Information Sciences and Documentation, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Institute of Medical Statistics, Information Sciences and Documentation, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Altgassen, Christoph" sort="Altgassen, Christoph" uniqKey="Altgassen C" first="Christoph" last="Altgassen">Christoph Altgassen</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Gynecology and Obstetrics, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Universitätsklinikum Schleswig-Holstein, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Greinke, Christiane" sort="Greinke, Christiane" uniqKey="Greinke C" first="Christiane" last="Greinke">Christiane Greinke</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="H Fner, Norman" sort="H Fner, Norman" uniqKey="H Fner N" first="Norman" last="H Fner">Norman H Fner</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Fishta, Alba" sort="Fishta, Alba" uniqKey="Fishta A" first="Alba" last="Fishta">Alba Fishta</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Gajda, Mieczyslaw" sort="Gajda, Mieczyslaw" uniqKey="Gajda M" first="Mieczyslaw" last="Gajda">Mieczyslaw Gajda</name><affiliation wicri:level="1"><nlm:aff id="A4"> Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Mahnert, Ute" sort="Mahnert, Ute" uniqKey="Mahnert U" first="Ute" last="Mahnert">Ute Mahnert</name><affiliation wicri:level="1"><nlm:aff id="A5"> Department of Gynecology and Obstetrics, Helios Klinikum Erfurt GmbH, Erfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Helios Klinikum Erfurt GmbH, Erfurt</wicri:regionArea><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation wicri:level="3"><nlm:aff id="A6"> Department of Gynecology and Obstetrics, Medizinische Hochschule Hannover, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Dimpfl, Thomas" sort="Dimpfl, Thomas" uniqKey="Dimpfl T" first="Thomas" last="Dimpfl">Thomas Dimpfl</name><affiliation wicri:level="3"><nlm:aff id="A7"> Department of Gynecology and Obstetrics, Klinikum Kassel GmbH, Kassel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Klinikum Kassel GmbH, Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Lenhard, Miriam" sort="Lenhard, Miriam" uniqKey="Lenhard M" first="Miriam" last="Lenhard">Miriam Lenhard</name><affiliation wicri:level="3"><nlm:aff id="A8"> Department of Gynecology and Obstetrics, Ludwig-Maximilians-University Munich, Campus Grosshadern, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Ludwig-Maximilians-University Munich, Campus Grosshadern, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Petry, K Ulrich" sort="Petry, K Ulrich" uniqKey="Petry K" first="K. Ulrich" last="Petry">K. Ulrich Petry</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Gynecology and Obstetrics, Klinikum Wolfsburg, Wolfsburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Klinikum Wolfsburg, Wolfsburg</wicri:regionArea><wicri:noRegion>Wolfsburg</wicri:noRegion><wicri:noRegion>Wolfsburg</wicri:noRegion><wicri:noRegion>Wolfsburg</wicri:noRegion></affiliation></author><author><name sortKey="Runnebaum, Ingo B" sort="Runnebaum, Ingo B" uniqKey="Runnebaum I" first="Ingo B." last="Runnebaum">Ingo B. Runnebaum</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Schneider, Achim" sort="Schneider, Achim" uniqKey="Schneider A" first="Achim" last="Schneider">Achim Schneider</name><affiliation wicri:level="3"><nlm:aff id="A10"> Institute for Cytology and Dysplasia, Fürstenbergkarree, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Institute for Cytology and Dysplasia, Fürstenbergkarree, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26008982</idno><idno type="pmc">4673218</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673218</idno><idno type="RBID">PMC:4673218</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000386</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000386</idno><idno type="wicri:Area/Pmc/Curation">000386</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000386</idno><idno type="wicri:Area/Pmc/Checkpoint">000F48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F48</idno><idno type="wicri:Area/Ncbi/Merge">007414</idno><idno type="wicri:Area/Ncbi/Curation">007414</idno><idno type="wicri:Area/Ncbi/Checkpoint">007414</idno><idno type="wicri:Area/Main/Merge">001952</idno><idno type="wicri:Area/Main/Curation">001950</idno><idno type="wicri:Area/Main/Exploration">001950</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status</title><author><name sortKey="Durst, Matthias" sort="Durst, Matthias" uniqKey="Durst M" first="Matthias" last="Dürst">Matthias Dürst</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Hoyer, Heike" sort="Hoyer, Heike" uniqKey="Hoyer H" first="Heike" last="Hoyer">Heike Hoyer</name><affiliation wicri:level="1"><nlm:aff id="A2"> Institute of Medical Statistics, Information Sciences and Documentation, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Institute of Medical Statistics, Information Sciences and Documentation, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Altgassen, Christoph" sort="Altgassen, Christoph" uniqKey="Altgassen C" first="Christoph" last="Altgassen">Christoph Altgassen</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Gynecology and Obstetrics, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Universitätsklinikum Schleswig-Holstein, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Greinke, Christiane" sort="Greinke, Christiane" uniqKey="Greinke C" first="Christiane" last="Greinke">Christiane Greinke</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="H Fner, Norman" sort="H Fner, Norman" uniqKey="H Fner N" first="Norman" last="H Fner">Norman H Fner</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Fishta, Alba" sort="Fishta, Alba" uniqKey="Fishta A" first="Alba" last="Fishta">Alba Fishta</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Gajda, Mieczyslaw" sort="Gajda, Mieczyslaw" uniqKey="Gajda M" first="Mieczyslaw" last="Gajda">Mieczyslaw Gajda</name><affiliation wicri:level="1"><nlm:aff id="A4"> Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Mahnert, Ute" sort="Mahnert, Ute" uniqKey="Mahnert U" first="Ute" last="Mahnert">Ute Mahnert</name><affiliation wicri:level="1"><nlm:aff id="A5"> Department of Gynecology and Obstetrics, Helios Klinikum Erfurt GmbH, Erfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Helios Klinikum Erfurt GmbH, Erfurt</wicri:regionArea><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation wicri:level="3"><nlm:aff id="A6"> Department of Gynecology and Obstetrics, Medizinische Hochschule Hannover, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Dimpfl, Thomas" sort="Dimpfl, Thomas" uniqKey="Dimpfl T" first="Thomas" last="Dimpfl">Thomas Dimpfl</name><affiliation wicri:level="3"><nlm:aff id="A7"> Department of Gynecology and Obstetrics, Klinikum Kassel GmbH, Kassel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Klinikum Kassel GmbH, Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Lenhard, Miriam" sort="Lenhard, Miriam" uniqKey="Lenhard M" first="Miriam" last="Lenhard">Miriam Lenhard</name><affiliation wicri:level="3"><nlm:aff id="A8"> Department of Gynecology and Obstetrics, Ludwig-Maximilians-University Munich, Campus Grosshadern, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Ludwig-Maximilians-University Munich, Campus Grosshadern, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Petry, K Ulrich" sort="Petry, K Ulrich" uniqKey="Petry K" first="K. Ulrich" last="Petry">K. Ulrich Petry</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Gynecology and Obstetrics, Klinikum Wolfsburg, Wolfsburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology and Obstetrics, Klinikum Wolfsburg, Wolfsburg</wicri:regionArea><wicri:noRegion>Wolfsburg</wicri:noRegion><wicri:noRegion>Wolfsburg</wicri:noRegion><wicri:noRegion>Wolfsburg</wicri:noRegion></affiliation></author><author><name sortKey="Runnebaum, Ingo B" sort="Runnebaum, Ingo B" uniqKey="Runnebaum I" first="Ingo B." last="Runnebaum">Ingo B. Runnebaum</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Schneider, Achim" sort="Schneider, Achim" uniqKey="Schneider A" first="Achim" last="Schneider">Achim Schneider</name><affiliation wicri:level="3"><nlm:aff id="A10"> Institute for Cytology and Dysplasia, Fürstenbergkarree, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Institute for Cytology and Dysplasia, Fürstenbergkarree, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Up to 15% of patients with cervical cancer and pN0-status develop recurrent-disease. This may be due to occult metastatic spread of tumor cells. We evaluated the use of human-papillomavirus-(HPV)-mRNA as a molecular marker for disseminated tumor cells to predict the risk of recurrence. For this prospective, multi-center prognostic study, 189 patients free of lymphnode metastases by conventional histopathology could be analyzed. All patients underwent complete lymphadenectomy. Of each sentinel node (SLN) a biopsy was taken for the detection of HPV-E6-E7-mRNA. Median follow-up time after surgery was 8.1 years. HPV-mRNA could be detected in SLN of 52 patients (27.5%). Recurrence was observed in 22 patients. Recurrence-free-survival was significantly longer for patients with HPV-negative SLN (log rank <italic>p</italic> = 0.002). By Cox regression analysis the hazard ratio (95%CI) for disease-recurrence was 3.8 (1.5 – 9.3, <italic>p</italic> = 0.004) for HPV-mRNA-positive compared to HPV-mRNA-negative patients. After adjustment for tumor size as the most influential covariate the HR was still 2.8 (1.1 – 7.0, <italic>p</italic> = 0.030). In patients with cervical cancer and tumor-free lymph nodes by conventional histopathology HPV-mRNA-positive SLN were of prognostic value independent of tumor size. Particularly, patients with tumors larger than 20mm diameter could possibly benefit from further risk stratification using HPV-mRNA as a molecular marker.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Delgado, G" uniqKey="Delgado G">G Delgado</name></author><author><name sortKey="Bundy, Bn" uniqKey="Bundy B">BN Bundy</name></author><author><name sortKey="Fowler, Wc" uniqKey="Fowler W">WC Fowler</name></author><author><name sortKey="Stehman, Fb" uniqKey="Stehman F">FB Stehman</name></author><author><name sortKey="Sevin, B" uniqKey="Sevin B">B Sevin</name></author><author><name sortKey="Creasman, Wt" uniqKey="Creasman W">WT Creasman</name></author><author><name sortKey="Major, F" uniqKey="Major F">F Major</name></author><author><name sortKey="Disaia, P" uniqKey="Disaia P">P DiSaia</name></author><author><name sortKey="Zaino, R" uniqKey="Zaino R">R Zaino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Look, Ky" uniqKey="Look K">KY Look</name></author><author><name sortKey="Brunetto, Vl" uniqKey="Brunetto V">VL Brunetto</name></author><author><name sortKey="Clarke Pearson, Dl" uniqKey="Clarke Pearson D">DL Clarke-Pearson</name></author><author><name sortKey="Averette, He" uniqKey="Averette H">HE Averette</name></author><author><name sortKey="Major, Fj" uniqKey="Major F">FJ Major</name></author><author><name sortKey="Alvarez, Rd" uniqKey="Alvarez R">RD Alvarez</name></author><author><name sortKey="Homesley, Hd" uniqKey="Homesley H">HD Homesley</name></author><author><name sortKey="Zaino, Rj" uniqKey="Zaino R">RJ Zaino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name></author><author><name sortKey="Wen, Dr" uniqKey="Wen D">DR Wen</name></author><author><name sortKey="Wong, Jh" uniqKey="Wong J">JH Wong</name></author><author><name sortKey="Economou, Js" uniqKey="Economou J">JS Economou</name></author><author><name sortKey="Cagle, La" uniqKey="Cagle L">LA Cagle</name></author><author><name sortKey="Storm, Fk" uniqKey="Storm F">FK Storm</name></author><author><name sortKey="Foshag, Lj" uniqKey="Foshag L">LJ Foshag</name></author><author><name sortKey="Cochran, Aj" uniqKey="Cochran A">AJ Cochran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altgassen, C" uniqKey="Altgassen C">C Altgassen</name></author><author><name sortKey="Hertel, H" uniqKey="Hertel H">H Hertel</name></author><author><name sortKey="Brandstadt, A" uniqKey="Brandstadt A">A Brandstadt</name></author><author><name sortKey="Kohler, C" uniqKey="Kohler C">C Kohler</name></author><author><name sortKey="Durst, M" uniqKey="Durst M">M Durst</name></author><author><name sortKey="Schneider, A" uniqKey="Schneider A">A Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darlin, L" uniqKey="Darlin L">L Darlin</name></author><author><name sortKey="Persson, J" uniqKey="Persson J">J Persson</name></author><author><name sortKey="Bossmar, T" uniqKey="Bossmar T">T Bossmar</name></author><author><name sortKey="Lindahl, B" uniqKey="Lindahl B">B Lindahl</name></author><author><name sortKey="Kannisto, P" uniqKey="Kannisto P">P Kannisto</name></author><author><name sortKey="Masback, A" uniqKey="Masback A">A Masback</name></author><author><name sortKey="Borgfeldt, C" uniqKey="Borgfeldt C">C Borgfeldt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cibula, D" uniqKey="Cibula D">D Cibula</name></author><author><name sortKey="Abu Rustum, Nr" uniqKey="Abu Rustum N">NR Abu-Rustum</name></author><author><name sortKey="Dusek, L" uniqKey="Dusek L">L Dusek</name></author><author><name sortKey="Slama, J" uniqKey="Slama J">J Slama</name></author><author><name sortKey="Zikan, M" uniqKey="Zikan M">M Zikan</name></author><author><name sortKey="Zaal, A" uniqKey="Zaal A">A Zaal</name></author><author><name sortKey="Sevcik, L" uniqKey="Sevcik L">L Sevcik</name></author><author><name sortKey="Kenter, G" uniqKey="Kenter G">G Kenter</name></author><author><name sortKey="Querleu, D" uniqKey="Querleu D">D Querleu</name></author><author><name sortKey="Jach, R" uniqKey="Jach R">R Jach</name></author><author><name sortKey="Bats, As" uniqKey="Bats A">AS Bats</name></author><author><name sortKey="Dyduch, G" uniqKey="Dyduch G">G Dyduch</name></author><author><name sortKey="Graf, P" uniqKey="Graf P">P Graf</name></author><author><name sortKey="Klat, J" uniqKey="Klat J">J Klat</name></author><author><name sortKey="Meijer, Cj" uniqKey="Meijer C">CJ Meijer</name></author><author><name sortKey="Mery, E" uniqKey="Mery E">E Mery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lecuru, F" uniqKey="Lecuru F">F Lecuru</name></author><author><name sortKey="Mathevet, P" uniqKey="Mathevet P">P Mathevet</name></author><author><name sortKey="Querleu, D" uniqKey="Querleu D">D Querleu</name></author><author><name sortKey="Leblanc, E" uniqKey="Leblanc E">E Leblanc</name></author><author><name sortKey="Morice, P" uniqKey="Morice P">P Morice</name></author><author><name sortKey="Darai, E" uniqKey="Darai E">E Darai</name></author><author><name sortKey="Marret, H" uniqKey="Marret H">H Marret</name></author><author><name sortKey="Magaud, L" uniqKey="Magaud L">L Magaud</name></author><author><name sortKey="Gillaizeau, F" uniqKey="Gillaizeau F">F Gillaizeau</name></author><author><name sortKey="Chatellier, G" uniqKey="Chatellier G">G Chatellier</name></author><author><name sortKey="Dargent, D" uniqKey="Dargent D">D Dargent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gortzak Uzan, L" uniqKey="Gortzak Uzan L">L Gortzak-Uzan</name></author><author><name sortKey="Jimenez, W" uniqKey="Jimenez W">W Jimenez</name></author><author><name sortKey="Nofech Mozes, S" uniqKey="Nofech Mozes S">S Nofech-Mozes</name></author><author><name sortKey="Ismiil, N" uniqKey="Ismiil N">N Ismiil</name></author><author><name sortKey="Khalifa, Ma" uniqKey="Khalifa M">MA Khalifa</name></author><author><name sortKey="Dube, V" uniqKey="Dube V">V Dube</name></author><author><name sortKey="Rosen, B" uniqKey="Rosen B">B Rosen</name></author><author><name sortKey="Murphy, J" uniqKey="Murphy J">J Murphy</name></author><author><name sortKey="Laframboise, S" uniqKey="Laframboise S">S Laframboise</name></author><author><name sortKey="Covens, A" uniqKey="Covens A">A Covens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Gf" uniqKey="Schwartz G">GF Schwartz</name></author><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U Veronesi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horn, Lc" uniqKey="Horn L">LC Horn</name></author><author><name sortKey="Hentschel, B" uniqKey="Hentschel B">B Hentschel</name></author><author><name sortKey="Fischer, U" uniqKey="Fischer U">U Fischer</name></author><author><name sortKey="Peter, D" uniqKey="Peter D">D Peter</name></author><author><name sortKey="Bilek, K" uniqKey="Bilek K">K Bilek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bostick, Pj" uniqKey="Bostick P">PJ Bostick</name></author><author><name sortKey="Chatterjee, S" uniqKey="Chatterjee S">S Chatterjee</name></author><author><name sortKey="Chi, Dd" uniqKey="Chi D">DD Chi</name></author><author><name sortKey="Huynh, Kt" uniqKey="Huynh K">KT Huynh</name></author><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Cote, R" uniqKey="Cote R">R Cote</name></author><author><name sortKey="Hoon, Ds" uniqKey="Hoon D">DS Hoon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Trappen, Po" uniqKey="Van Trappen P">PO Van Trappen</name></author><author><name sortKey="Gyselman, Vg" uniqKey="Gyselman V">VG Gyselman</name></author><author><name sortKey="Lowe, Dg" uniqKey="Lowe D">DG Lowe</name></author><author><name sortKey="Ryan, A" uniqKey="Ryan A">A Ryan</name></author><author><name sortKey="Oram, Dh" uniqKey="Oram D">DH Oram</name></author><author><name sortKey="Bosze, P" uniqKey="Bosze P">P Bosze</name></author><author><name sortKey="Weekes, Ar" uniqKey="Weekes A">AR Weekes</name></author><author><name sortKey="Shepherd, Jh" uniqKey="Shepherd J">JH Shepherd</name></author><author><name sortKey="Dorudi, S" uniqKey="Dorudi S">S Dorudi</name></author><author><name sortKey="Bustin, Sa" uniqKey="Bustin S">SA Bustin</name></author><author><name sortKey="Jacobs, Ij" uniqKey="Jacobs I">IJ Jacobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bleiweiss, Ij" uniqKey="Bleiweiss I">IJ Bleiweiss</name></author><author><name sortKey="Nagi, Cs" uniqKey="Nagi C">CS Nagi</name></author><author><name sortKey="Jaffer, S" uniqKey="Jaffer S">S Jaffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walboomers, Jm" uniqKey="Walboomers J">JM Walboomers</name></author><author><name sortKey="Jacobs, Mv" uniqKey="Jacobs M">MV Jacobs</name></author><author><name sortKey="Manos, Mm" uniqKey="Manos M">MM Manos</name></author><author><name sortKey="Bosch, Fx" uniqKey="Bosch F">FX Bosch</name></author><author><name sortKey="Kummer, Ja" uniqKey="Kummer J">JA Kummer</name></author><author><name sortKey="Shah, Kv" uniqKey="Shah K">KV Shah</name></author><author><name sortKey="Snijders, Pj" uniqKey="Snijders P">PJ Snijders</name></author><author><name sortKey="Peto, J" uniqKey="Peto J">J Peto</name></author><author><name sortKey="Meijer, Cj" uniqKey="Meijer C">CJ Meijer</name></author><author><name sortKey="Munoz, N" uniqKey="Munoz N">N Munoz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="H Fner, N" uniqKey="H Fner N">N Häfner</name></author><author><name sortKey="Driesch, C" uniqKey="Driesch C">C Driesch</name></author><author><name sortKey="Gajda, M" uniqKey="Gajda M">M Gajda</name></author><author><name sortKey="Jansen, L" uniqKey="Jansen L">L Jansen</name></author><author><name sortKey="Kirchmayr, R" uniqKey="Kirchmayr R">R Kirchmayr</name></author><author><name sortKey="Runnebaum, Ib" uniqKey="Runnebaum I">IB Runnebaum</name></author><author><name sortKey="Durst, M" uniqKey="Durst M">M Dürst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="H Fner, N" uniqKey="H Fner N">N Häfner</name></author><author><name sortKey="Gajda, M" uniqKey="Gajda M">M Gajda</name></author><author><name sortKey="Altgassen, C" uniqKey="Altgassen C">C Altgassen</name></author><author><name sortKey="Hertel, H" uniqKey="Hertel H">H Hertel</name></author><author><name sortKey="Greinke, C" uniqKey="Greinke C">C Greinke</name></author><author><name sortKey="Hillemanns, P" uniqKey="Hillemanns P">P Hillemanns</name></author><author><name sortKey="Schneider, A" uniqKey="Schneider A">A Schneider</name></author><author><name sortKey="Durst, M" uniqKey="Durst M">M Dürst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcshane, Lm" uniqKey="Mcshane L">LM McShane</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author><author><name sortKey="Sauerbrei, W" uniqKey="Sauerbrei W">W Sauerbrei</name></author><author><name sortKey="Taube, Se" uniqKey="Taube S">SE Taube</name></author><author><name sortKey="Gion, M" uniqKey="Gion M">M Gion</name></author><author><name sortKey="Clark, Gm" uniqKey="Clark G">GM Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, Mv" uniqKey="Jacobs M">MV Jacobs</name></author><author><name sortKey="Snijders, Pj" uniqKey="Snijders P">PJ Snijders</name></author><author><name sortKey="Van Den Brule, Aj" uniqKey="Van Den Brule A">AJ van den Brule</name></author><author><name sortKey="Helmerhorst, Tj" uniqKey="Helmerhorst T">TJ Helmerhorst</name></author><author><name sortKey="Meijer, Cj" uniqKey="Meijer C">CJ Meijer</name></author><author><name sortKey="Walboomers, Jm" uniqKey="Walboomers J">JM Walboomers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Zm" uniqKey="Zheng Z">ZM Zheng</name></author><author><name sortKey="Baker, Cc" uniqKey="Baker C">CC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peduzzi, P" uniqKey="Peduzzi P">P Peduzzi</name></author><author><name sortKey="Concato, J" uniqKey="Concato J">J Concato</name></author><author><name sortKey="Feinstein, Ar" uniqKey="Feinstein A">AR Feinstein</name></author><author><name sortKey="Holford, Tr" uniqKey="Holford T">TR Holford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author><author><name sortKey="Mcshane, Lm" uniqKey="Mcshane L">LM McShane</name></author><author><name sortKey="Sauerbrei, W" uniqKey="Sauerbrei W">W Sauerbrei</name></author><author><name sortKey="Taube, Se" uniqKey="Taube S">SE Taube</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schemper, M" uniqKey="Schemper M">M Schemper</name></author><author><name sortKey="Smith, Tl" uniqKey="Smith T">TL Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Euscher, Ed" uniqKey="Euscher E">ED Euscher</name></author><author><name sortKey="Malpica, A" uniqKey="Malpica A">A Malpica</name></author><author><name sortKey="Atkinson, En" uniqKey="Atkinson E">EN Atkinson</name></author><author><name sortKey="Levenback, Cf" uniqKey="Levenback C">CF Levenback</name></author><author><name sortKey="Frumovitz, M" uniqKey="Frumovitz M">M Frumovitz</name></author><author><name sortKey="Deavers, Mt" uniqKey="Deavers M">MT Deavers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patani, N" uniqKey="Patani N">N Patani</name></author><author><name sortKey="Mokbel, K" uniqKey="Mokbel K">K Mokbel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name></author><author><name sortKey="Hoon, Ds" uniqKey="Hoon D">DS Hoon</name></author><author><name sortKey="Cochran, Aj" uniqKey="Cochran A">AJ Cochran</name></author><author><name sortKey="Turner, Rr" uniqKey="Turner R">RR Turner</name></author><author><name sortKey="Essner, R" uniqKey="Essner R">R Essner</name></author><author><name sortKey="Takeuchi, H" uniqKey="Takeuchi H">H Takeuchi</name></author><author><name sortKey="Wanek, La" uniqKey="Wanek L">LA Wanek</name></author><author><name sortKey="Glass, E" uniqKey="Glass E">E Glass</name></author><author><name sortKey="Foshag, Lj" uniqKey="Foshag L">LJ Foshag</name></author><author><name sortKey="Hsueh, Ec" uniqKey="Hsueh E">EC Hsueh</name></author><author><name sortKey="Bilchik, Aj" uniqKey="Bilchik A">AJ Bilchik</name></author><author><name sortKey="Elashoff, D" uniqKey="Elashoff D">D Elashoff</name></author><author><name sortKey="Elashoff, R" uniqKey="Elashoff R">R Elashoff</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li><li>Bavière</li><li>Berlin</li><li>District de Haute-Bavière</li><li>District de Kassel</li><li>Hesse (Land)</li></region><settlement><li>Berlin</li><li>Cassel (Hesse)</li><li>Hanovre</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Durst, Matthias" sort="Durst, Matthias" uniqKey="Durst M" first="Matthias" last="Dürst">Matthias Dürst</name></noRegion><name sortKey="Altgassen, Christoph" sort="Altgassen, Christoph" uniqKey="Altgassen C" first="Christoph" last="Altgassen">Christoph Altgassen</name><name sortKey="Dimpfl, Thomas" sort="Dimpfl, Thomas" uniqKey="Dimpfl T" first="Thomas" last="Dimpfl">Thomas Dimpfl</name><name sortKey="Fishta, Alba" sort="Fishta, Alba" uniqKey="Fishta A" first="Alba" last="Fishta">Alba Fishta</name><name sortKey="Gajda, Mieczyslaw" sort="Gajda, Mieczyslaw" uniqKey="Gajda M" first="Mieczyslaw" last="Gajda">Mieczyslaw Gajda</name><name sortKey="Greinke, Christiane" sort="Greinke, Christiane" uniqKey="Greinke C" first="Christiane" last="Greinke">Christiane Greinke</name><name sortKey="H Fner, Norman" sort="H Fner, Norman" uniqKey="H Fner N" first="Norman" last="H Fner">Norman H Fner</name><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><name sortKey="Hoyer, Heike" sort="Hoyer, Heike" uniqKey="Hoyer H" first="Heike" last="Hoyer">Heike Hoyer</name><name sortKey="Lenhard, Miriam" sort="Lenhard, Miriam" uniqKey="Lenhard M" first="Miriam" last="Lenhard">Miriam Lenhard</name><name sortKey="Mahnert, Ute" sort="Mahnert, Ute" uniqKey="Mahnert U" first="Ute" last="Mahnert">Ute Mahnert</name><name sortKey="Petry, K Ulrich" sort="Petry, K Ulrich" uniqKey="Petry K" first="K. Ulrich" last="Petry">K. Ulrich Petry</name><name sortKey="Runnebaum, Ingo B" sort="Runnebaum, Ingo B" uniqKey="Runnebaum I" first="Ingo B." last="Runnebaum">Ingo B. Runnebaum</name><name sortKey="Schneider, Achim" sort="Schneider, Achim" uniqKey="Schneider A" first="Achim" last="Schneider">Achim Schneider</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001950 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001950 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4673218
|texte= Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26008982" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |